Scientific literature

A list of papers that I mention in this blog, with brief comments.

Nutrition and supplements

  • Broccoli, cabbage and similar vegetables have protective effects against cancer (Cell, 2020).  This is of no interest because I've got the disease already.
  • There are no clear guidelines or recommended regimes of dietary modification for patients with cancer (Nature, 2020).

Fasting

  • Fasting might protect healthy cells from the effects of chemotherapy, might potentiate the effect of chemotherapy on cancer cells, and might even directly damage cancer cells (Science Translational Medicine, 2012).  This sounds really intriguing.  Fast for two days before chemotherapy and for one day afterwards and significantly improve the outcome.
  • Fasting and fasting-mimicking diets might combine beneficially with chemotherapy (Nature Reviews Cancer, 2018).  They might increase treatment efficacy, prevent resistance acquisition and reduce side effects.  This is not uncontested (Nature Reviews Cancer, 2019) but the authors are convinced (Nature Reviews Cancer, 2019).

Vitamin C

  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells (Science, 2015).  Large quantities are needed, and it has to be given intravenously.
  • Intravenous Vitamin C potentiates the beneficial effect of fasting against KRAS mutated cancers (Nature Communications, 2020).  I'd do this in a jiffy, but's not an approved therapy.

T cell therapy

  • Adoptive T cell therapy (Science, 2020) aims to engineer T cells to specifically kill cancer cells.
  • The STING pathway can be stimulated (Science, 2020; Science, 2020) for a more robust T cell response against cancer cells.

The biology of KRAS

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